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Applications and Articles Applications and Articles


PARTICLE SIZING


Particle Sizing: what is Baseline Index and why is it important?

The baseline index, abbreviated as BI, is a metric that can be used to quantify the impact of dust contamination on a given DLS measurement. Within the vernacular of light scattering, dust is often loosely defined, referring to any minor component too large to properly disperse, moving due to gravity, rather than Brownian motion...Read More


Powerful Tools for Drug Delivery Characterization

Liposomes are commonly used in drug delivery applications to encapsulate and deliver bioactive cargo molecules such as oligonucleotides and proteins. A new application is available that discusses how Liposomes may be characterized using Dynamic Light Scattering (DLS) and Zeta Potential techniques...Read More


How Does Baseline Index Impact DLS?

The baseline index, abbreviated as BI, is a metric that can be used to quantify the impact of dust contamination on a given DLS measurement. Within the vernacular of light scattering, dust is often loosely defined, referring to any minor component too large to properly disperse, moving due to gravity, rather than Brownian motion...Read More


Nanosphere Research Using Dynamic Light Scattering

Science Direct presented a study entitled, “Self-Assembly Of B-Cyclodextrin And Pluronic Into Hollow Nanospheres In Aqueous Solution” which investigated self-assembly of b-cyclodextrin (b-CD) and tri-block pluronic (PEG–PPG–PEG) in an aqueous solution...Read More


Automation of pH-titrations using the BI-ZTU

The stability of dispersible nanomaterials often depends on having a high surface charge. These charges are often pH dependent, especially for surface chemistries with acidic or basic functionalities. A titration can be performed to rapidly profile a range of solution conditions to determine...Read More


Enclosed Light Scattering Instruments and Goniometer Based Light Scattering Instruments - A Comparison

When the acquisition of a new instrument for particle sizing is being considered, two options are presented: a goniometer based or an enclosed light scattering instrument... Read More


Analysis of Virus Particles in Media by Dynamic Light Scattering

Traditional visual methods of observing virus particles in solution give a snapshot of a very small sampling volume, while the technique of particle analysis using dynamic light scattering yields an ensemble average of particles present in the solutions... Read More


Light Scattering Probes the Properties of Complex Colloids

The BI-200SM dynamic and static light scattering goniometer and BI-9000AT correlator as a photon correlation spectroscopy system has helped the Bristol Colloid Centre, a commercial enterprise founded by the University of Bristol (UK), probe the properties of a variety of complex colloidal systems... Read More


Guide to Making Useful Measurements of Monoclonal Antibodies (mAbs) with Dynamic Light Scattering

DLS relies on the principle that freely diffusing material, moving randomly due to Brownian motion, will produce rapid fluctuations in scattered laser light.... Read More


Why is Ionic Strength Relevant to DLS Measurements?

The measurement of particle size by dynamic light scattering (DLS) is heavily dependent on the stability of materials being investigated... Read More


NanoBrook 90Plus Particle Size Analyzer Effective in Poorna Chandrodayan Research

Anoop Austin from Rumi Herbals’ R&D Centre, presented a study that demonstrated mercurial and gold preparation in nanoparticle form. The study was entitled... Read More


Why are DLS measurements in high concentration solutions difficult?

Dynamic Light Scattering (DLS) is an effective measurement technique used for measuring the hydrodynamic size of common nanomaterials including colloids, nanoparticles, proteins, and polymers... Read More


Micellar Water Characterization: A Laser Light Scattering Application

Micellar waters are the trendy new facial cleanser that boasts its ability to clean skin without irritation. We present results from dynamic light scattering (DLS), phase analysis light scattering (PALS)... Read More


Aggregation Detection by Dynamic Light Scattering

Testa Analytical Solutions e.K reports on how its NanoBrook Omni particle size analyser and BI-ZTU autotitrator can be used together to detect the onset of aggregation in nanoparticles... Read More


Characterising Liposomes & Liposome-drug Conjugates

Liposomes or Lipid-drug conjugates used as targeted drug delivery systems are hot topics in the field of pharmaceutical research... Read More


What is a particle

Elementary vs Fine Particles: The question embodied in the title might seem strange until you consider the many... Read More


What is Particle Size Distribution Weighting

Some particle size instruments determine size for individual particles. They are single particle counters. Some instruments... Read More


A guide to choosing a Particle Sizer

Introduction: The choice of a particle Size analyzer has never been more difficult. There are several techniques from which to choose and variations within... Read More


A Guide to Determination of Particle Size

When any material of one phase is dispersed into a second phase, an "interface" is created between the two phases... Read More


Particle Sizing using DCP for ASTM Carbon Black

The principles of particle sizing using a disc centrifuge photosedimentometer are reviewed. The importance of the extinction... Read More


Guide for DLS sample preparation

This document is intended to help the user determine the best way to prepare samples for dynamic light scattering (DLS) measurements... Read More