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Automation of pH-titrations using the BI-ZTU

The stability of dispersible nanomaterials often depends on having a high surface charge. These charges are often pH dependent, especially for surface chemistries with acidic or basic functionalities. A titration can be performed to rapidly profile a range of solution conditions to determine how stability might change with respect to formulation pH. This is especially useful for protein containing formulations, where the components often contain mixtures of positively and negatively charged sidechains.