Liposomes or Lipid-drug conjugates used as targeted drug delivery systems are hot topics in the field of pharmaceutical research. The size and charge at the surface of the particle plays a deciding role for proper gastrointestinal uptake of the synthesized Liposome Drug Conjugates (LDC) nanoparticles and their systemic clearance by the reticuloendothelial system. It is therefore always important to determine the size of LDC nanoparticles accurately. A new application note is available describing how the Nanobrook ZetaPALS instrument, using a phase analysis light scattering technique, has been used to accurately determine the size and surface charge of liposomes, exosomes and microvesicles.
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